New Generation Endomicroscopy Technologies and Translational Nano-biophotonics Imaging
Details
Speaker:
Dr. Xingde Li
Associate Professor,
Department of Biomedical Engineering,
Johns Hopkins University
Date:
Monday, 6 July 2009
Time:
11:00 am - 12:00 noon
Venue:
Theatre B,
Chow Yei Ching Building, HKU
Abstract:
Clinical translation of high-resolution optical imaging technologies, such as OCT, confocal, two-photon fluorescence (TPF) and second-harmonic generation (SHG) microscopy, faces two critical needs: (1) endomicroscopes/fiber-optic sensors that can access internal organs, and (2) methods that can enhance the limited intrinsic molecular contrast between normal and disease tissues. In this presentation, we will report on our recent research on developing ultrathin fiber-optic endomicroscopy technologies, which are instrumental for translating real-time OCT, TPF and SHG microscopy technologies into in vivo and clinical practice including early disease diagnosis and guidance of various interventions. Technical challenges and solutions will be discussed. We will also present our initial approaches to improve molecular sensitivity and specificity of the optical imaging technologies by developing innovative structured metallic nanoparticles and polymeric nanocapsules, which are potentially clinically translatable. In addition, we will demonstrate some exemplary applications of these biophotonic imaging technologies, including (1) assessment of normal and stimulated tissue regeneration processes, (2) detection of abnormalities in the gastrointestinal tract (such as Barrett’s, subsquamous Barrett’s epithelium and cancer), and (3) two-photon auto-fluorescence imaging of biological tissues with a 2.4 mm scanning fiber-optic endomicroscope for the first time.
Biography of the speaker:
Xingde Li received his Ph.D. from the Department of Physics University of Pennsylvania in 1998. He joined the Ultrafast Optics Group at the Research Laboratory of Electronics of MIT as a Postdoctoral Research Associate, conducting research in the area of Biomedical Optics. He became an Assistant Professor at the Department of Bioengineering University of Washington in 2001 and was promoted to an Associate Professor with tenure in 2007. He joined the Department of Biomedical Engineering at the Johns Hopkins University in 2009, is currently an Associate Professor of BME and Electrical and Computer Engineering. He has been serving as conference session chairs and chairs for many conferences including Gordon Research Conferences (2008, 2010), Biomedical Topical Conference on OCT (2010), Photonics Asia 2007, ACP2009 etc, and the chair of the Emerging Technologies Committee of the IEEE-Engineering in Medicine and Biology Society since 2006. Dr. Li received the Teacher/Mentor of the Year Award (UW Bioengineering) in 2002, the NSF Career Award in 2004, and the International IADR/GlaxoSmithKline Innovation in Oral Care Award in 2009.
Enquiries:
kitty@eee.hku.hk