2019/2020 IEEE UFFC Distinguished Lecture: Preclinical research with light and sound: shear wave imaging and photoacoustic imaging of 3D cell culture systems
03 Apr, 2019 (Wed)
2:30 pm - 3:30 pm
Chow Yei Ching Lecture Theater A,

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Prof. Pai-Chi Li
Distinguished Professor,
Department of Electrical Engineering and Institute of Biomedical Electronics and Bioinformatics,
National Taiwan University


Prof. Pai-Chi Li

Recent studies from drug screening and disease progression have shown that 3D cell culture can better represent the in vivo or clinical condition compared to 2D monolayer culture. However, due to the limited optical transparency, characterization of the live 3D cell culture model is often challenging and fails to extract further information this culture system can provide. In this lecture, I will cover the recent development of shear wave elasticity imaging (SWEI) and photoacoustic (PA) imaging to study 3D culture systems. A 3D optical resolution PA microscope (OR-PAM) along with molecular labeling has been developed to study cell movement and cell-cell interactions. In addition, novel ultrasound- and optics-based shear wave imaging methods have been used to non-invasively quantify the matrix stiffness in 3D culture condition. Both techniques were developed to demonstrate the correlation between matrix stiffness and T cell interstitial migration during immunotherapy. The goal of this lecture is to present the influential role of these combinatory techniques from optics and ultrasound in in vitro research and the development of new treatment strategies.


Biography of the speaker:
Pai-Chi Li is the TBF Chair in Biotechnology, and he was the Getac Chair as well as the Y. Z. Hsu Science Chair Professor. He received the B.S. degree in Electrical Engineering from National Taiwan University in 1987, and the M.S. and Ph.D. degrees from the University of Michigan, Ann Arbor in 1990 and 1994, respectively, both in Electrical Engineering: Systems. He joined Acuson Corporation, Mountain View, CA, as a member of the Technical Staff in June 1994. His work in Acuson was primarily in the areas of medical ultrasonic imaging system design for both cardiology and general imaging applications. In August 1997, he went back to National Taiwan University, where he is currently Vice President for Research and Development. He is Distinguished Professor of Department of Electrical Engineering and Institute of Biomedical Electronics and Bioinformatics. He was Associate Dean of College of Electrical Engineering and Computer Science from 2015-2018, and. He served as Founding Director of Institute of Biomedical Electronics and Bioinformatics in 2006-2009 and National Taiwan University Yong-Lin Biomedical Engineering Center in 2009. His current research interests include biomedical ultrasound and medical devices. Dr. Li is IEEE Fellow, IAMBE Fellow, AIUM Fellow and SPIE Fellow. He was also Editor-in-Chief of Journal of Medical and Biological Engineering, and has been Associate Editor of Ultrasound in Medicine and Biology, Associate Editor of IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, and on the Editorial Board of Ultrasonic Imaging and Photoacoustics. He has won numerous awards including Distinguished Research Award, the Dr. Wu Dayou Research Award and Distinguished Industrial Collaboration Award.


All are welcome.


Dr. W.N. Lee

Most seminars are open to the general public, free of charge, unless otherwise stated. Registration is not required. Arrangement for car parking facilities on campus please contact us for details.

For enquiries, please contact:
Department of Electrical and Electronic Engineering,
Room 601, Chow Yei Ching Building,
Pokfulam Road, Hong Kong
Tel: (852) 3917 7093
Email: seminar@eee.hku.hk