The curious case of the Contrast Microbubble
18 Oct, 2019 (Fri)
11:00 am
Room 603, Chow Yei Ching Building

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Prof. Vassilis Sboros
Institute of Biological Chemistry,
Biophysics and Bioengineering,
Heriot-Watt University, Edinburgh, UK.


Prof. Vassilis Sboros

The quantification of microvascular flow, often termed perfusion, using contrast enhanced ultrasound (CEUS) is being researched over 30 years. Microbubble (MB) technologies further include the potential to achieve molecularly targeted imaging, enhancement of cell porosity, thrombolysis and drug/gene delivery.

The consensus in the scientific community is that the progress of the field has been slower than originally envisaged. In reviewing the achievements of the field since its inception in 1968 it is important to appreciate that the new territories that CEUS had to explore are in the areas of physics, signal and image processing, and in vivo implementation. This ever growing multidisciplinary effort has overcome many challenges that were not originally anticipated. Central to this is the lack of high quality experimental data that enable a thorough understanding of MB behaviour under realistic ultrasound fields and in realistic in vivo experimental settings.

The necessity of investigating the acoustics of single MBs stems from the lack of a single or a predictable distribution of their acoustic responses, a problem that is particularly enhanced in vivo, hindering the development and optimisation of signal and image processing algorithms. Single MB acoustics measurements have provided high quality data that aid the development of MB theory and also contribute independently to signal processing research. This is more apparent today with the advent of new super-resolution imaging that draw from this knowledge and successfully implement methodologies that are established in astronomy, optical microscopy and other fields of sensing.


Biography of the speaker:

Prof Vassilis Sboros is a physicist with a Ph.D. on ultrasound contrast imaging. In his early research career he investigated the physics of contrast microbubbles and the engineering of imaging them, including signal and image processing. As a British Heart Foundation fellow (2007-2011) he expanded his multidisciplinary research using animal models of angiogenesis. This enabled the translation of his work into clinical imaging applications. His current research interests focus on the development on new super-resolution imaging tools that are applicable in the clinic.


Dr. W.N. Lee

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