Towards optimal nanobiointerface: molecular aspects of cellular targeting with nanoparticles
Date:
20 May, 2019 (Mon)
Time:
3:30 pm - 4:30 pm
Location:
Room 603, Chow Yei Ching Building

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Speaker

Dr Petr Cigler
Synthetic Nanochemistry, Head
Institute of Organic Chemistry and Biochemistry of the CAS
Prague, Czech Republic

Abstract

Dr. Petr Cigler

Abstract:

Nanoparticles used for biological applications provide range of imaging modalities and possibility of polyvalent display of molecules. Attachment of ligands to nanoparticles leads for selective and highly effective targeting of biological receptors. However, the interface of nanoparticles has to be optimized in terms of non-specific binding, which can strongly reduce the advantages of multivalent binding and interaction selectivity. In the talk, I will exemplify strategies for colloidal stabilization of nanoparticles under physiological conditions, coatings of nanoparticles with biocompatible polymers and influence of the coating strategies and ligand attachment on targeting of various cancer cells. The results obtained using diamond nanoparticles and chemically reprogrammed virus-like particles will be discussed.

 

Biography of the speaker:

Petr Cigler received his PhD at UCT Prague (2008), afterwards he did postdoc at The Scripps Research Institute, La Jolla, USA. Since 2013 he has been a head of Synthetic Nanochemistry research group at Institute of organic chemistry and biochemistry of the CAS, Prague. His current research interests include nanoparticles surface chemistry, their biointerface, and their applications in biomedicine and sensors.


Organizer

Dr. Z. Chu

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Department of Electrical and Electronic Engineering,
Room 601, Chow Yei Ching Building,
Pokfulam Road, Hong Kong
Tel: (852) 2859 7093
Email: seminar@eee.hku.hk